A01Elucidation of neural mechanism underlying model-based decision making using optogenetic manipulation and imaging of the central serotonergic system

 It has been speculated that serotonin release in the forebrain is involved in model-based　decision making. However, there is so far no direct evidence proving this hypothesis because there had been no method that selectively and temporally-specifically controls or observes the serotonergic activity. Therefore, we aimed at obtaining direct evidence about the roles of serotonergic activity in model-based decision making using recently developed optogenetic/imaging (genetically encoded calcium indicator) tools.